Title: |
Applications of ION Pair HPLC in Determination of Metformin Hydrochloride and Linagliptin in Tablet
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Authors: |
Chung Duong Dinh, Trang Nguyen Thi Thu, Quan Nguyen Huu Khanh, Yen Nguyen Thi Ngoc |
Source: |
International Journal of Latest Engineering Research and Applications, pp 01 - 07, Vol 08 - No. 09, 2023 |
Abstract: |
Introduction: The combination form of metformin and linagliptin improves glucose metabolism in treating type 2 diabetes. Objective: Establishing an analytical process to determine metformin and linagliptin in tablets by reverse-phase high-performance liquid chromatography (Rp-HPLC). Methods: Various parameters, including detection wavelength, mobile phase, stationary phase, SDS and ion concentration, pH value, flow rates, sample injection volumes, and column temperatures, were systematically investigated to optimize the chromatographic procedure. Results: Optimized chromatographic conditions for determining metformin and linagliptin are followed: Zorbar eclipse plus C18 column (100 x 4.6 mm, 3.5 μm), PDA detector (detection wavelength of 226 nm). The mobile phase was a mixture of methanol, acetonitrile, and phosphate buffer solution containing 1.75 mM SDS at pH 6.8 (7:33:60, v/v/v); Flow rate was 1 mL/min; Sample injection volume was 10 μl; and the column oven temperature was set at 40oC. The linear ranges of metformin and linagliptin are 7.66 - 45.97 μg/mL and 1.25 - 7.52 μg/mL, respectively (R2> 0.999). A metformin and linagliptin quantification method has been successfully established and validated by the Rp-HPLC method. Conclusion: The procedure was developed and validated according to ICH guidelines and applied to determine metformin and linagliptin in combination tablets. |
Keywords: |
Metformin hydrochloride, Linagliptin, Rp-HPLC, Validation |
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DOI: |
10.56581/IJLERA.8.9.01-07 |
Title: |
Some Methods and Algoriths for Evaluation of Well Equipment and Regime Parameters in Rod, Depth Pump Oil Wells
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Authors: |
Guluyev G.A., Pashayev F.H., Jafarov J.M. |
Source: |
International Journal of Latest Engineering Research and Applications, pp 08 - 18, Vol 08 - No. 09, 2023 |
Abstract: |
The article develops methods and algorithms using the construction and fuzzy evaluation of experimental distribution functions of dynamograms to evaluate the selection of well equipment and modes in the diagnostic and control systems of rod, deep pump oil wells. Informative identification signs were formed from the values of the experimental distribution function of dynamograms. A measure of proximity between the informational characteristics of the wells selected as the reference and the wells whose current status will be determined was determined, and the identification algorithm of dynamograms and wells was given by this measurement.
Several modes were selected for fuzzy assessment of well equipment and mode selection and appropriate mebership functions were identified. Examples of valuation rules using the values of mebership functions have been identified. The article presents fragments of software modules created. |
Keywords: |
Dynamogram, experimental distribution function, filling percentage, informative signs, proximity size, identification, mebership function, fuzzy evaluation, fuzzy rules. |
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DOI: |
10.56581/IJLERA.8.9.08-18 |
Title: |
Testing the random walk of stock price returns on the UMOA’S financial market
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Authors: |
Kouassi Aké Serge Pascal |
Source: |
International Journal of Latest Engineering Research and Applications, pp 19 - 26, Vol 08 - No. 09, 2023 |
Abstract: |
As part of the analysis of the behavior of financial asset prices, the objective of this study is to test the hypothesis of the random walk of stock prices on the BRVM regional financial market. Based on stock market returns calculated over the period from September 18 to December 30, 2022, stationarity tests and the use of an integrated autoregressive moving average model were used. The results show that the hypothesis of the random walk of returns of the BRVM10 index is verified and that the UMOA’s regional financial market is efficient in its weak form. |
Keywords: |
Random walk, informational efficiency, weak form, BRVM 10, stationarity, ARIMA |
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DOI: |
10.56581/IJLERA.8.9.19-26 |
Title: |
Intelligent Management of Trees for Environmental Harmony
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Authors: |
Tai-Tien Chen, Mei-Hsin Chen, Tien-Yin Chou |
Source: |
International Journal of Latest Engineering Research and Applications, pp 27 - 33, Vol 08 - No. 09, 2023 |
Abstract: |
In alignment with the United Nations Sustainable Development Goals (SDGs) and the 2050 net-zero carbon emissions target, the Taichung City Government has taken upon itself the mission of realizing a vision of sustainable coexistence between humanity and the natural environment. The Taichung City Government actively promotes various initiatives related to urban air purification, diverse landscape planning, and eco-friendly living spaces, including projects such as the Beautiful Life Project, reforestation of natural forests, and the beautification of green corridors. These projects aim to transform Taichung City into a leading sustainable urban center committed to achieving net-zero carbon emissions. To effectively manage the increasing number of plantations, the local government has harnessed spatial information technology and cloud-based management. Innovative solutions include tree planting and maintenance records, AI-powered plant maintenance management, and a mobile app for tree inspection and reporting. These measures align with Taichung City's goal of becoming a competent, low-carbon, green urban hub. |
Keywords: |
Sustainable, Beautiful Life Project, Green Corridor Beautification, Planting Management, Smart Management |
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DOI: |
10.56581/IJLERA.8.9.27-33 |
Title: |
Standardizing Process for Freeze-Dried Yogurt Fortified with Noni Juice
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Authors: |
Hong Tran Thi Kim, Trang Nguyen Huu Phuoc |
Source: |
International Journal of Latest Engineering Research and Applications, pp 34 - 40, Vol 08 - No. 09, 2023 |
Abstract: |
This study presents a process for producing freeze-dried yogurt with added noni juice using the freeze-drying method. We conducted research to determine the factors that influence the fermentation process of yogurt with added noni juice. This included investigating the ratio of swentenned condensed milk and UHT fresh milk-plain (1:2, 1:4 and 1:6 v/v), fermentation temperature (38°C, 42°C, and 46°C), and incubation time (8 hours, 10 hours, and 12 hours). Our goal was to find the optimal fermentation conditions that would result in freeze-dried yogurt with the best sensory quality and highest fermentation ability. The experimental results indicate that the optimal ratio of sweetened condensed milk to fresh milk for producing high-quality yogurt fortified with noni juice is 1:6 (v/v). Fermenting process at a temperature of 42°C for 10 hours yielded the best result of yogurt. Additionally, freezing the yogurt at -20°C for 4 hours and evaporating it at a temperature of 45°C for 10 hours resulted in a freeze-dried yogurt product with superior chemical composition and sensory properties |
Keywords: |
noni juice, freeze-fried yogurt, fermented milk |
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